Denosumab for the treatment of joint and bone diseases

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Denosumab for the treatment of joint and bone diseases

Rheumatoid arthritis (RA) is a representative inflammatory disease characterized with systemic, chronic and destructive synovitis and subsequent bone destruction that causes severe disability and mortality. Since joint destruction occurs from the early disease, its diagnosis and treatment have to be done timely. The combinational use of methotrexate and biologics targeting TNF and IL-6 has revo...

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Metastatic bone disease has a major impact on both the morbidity and mortality of patients. Antiresorptive bisphosphonates have revolutionized treatment and outcomes for patients with bone metastases, but pain and other skeletal complications still occur, adversely affecting quality of life and survival. Recent understanding of the bone microenvironment has highlighted the importance of RANK, i...

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Bone and Joint Diseases

I Illich, I, Medical Nemesis. London, Calder and Boyars, 1974. 2J7ournal of Medical Ethics, 1975, 1, 78-80. 3Campbell, A V, Moral Dilemma in Medicine, 2nd edn. Edinburgh/London, Churchill Livingstone, 1975. 4 Maxwell, R, Health Care: The Growing Dilemma. New York, McKinsey and Co, 1974. 5 Cochrane, A L, Effectiveness and Efficiency. London, Nuffield Hospitals Trust, 1972. 6 Berlin, I, in Politi...

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ژورنال

عنوان ژورنال: Inflammation and Regeneration

سال: 2011

ISSN: 1880-9693,1880-8190

DOI: 10.2492/inflammregen.31.344